Excerpts from A High With Your Fries? Even If Fast Food Is Not As Additive As Tobacco It Still Merits A Health Warning    But what if some obese people are actually victims of the type of food sold in fast-food outlets?  Absurd as it may sound, there is a growing body of evidence pointing in this direction.    Fats and simple sugars can act on the brain in the same way as nicotine and heroin.    Even if fast food is not addictive, the lawyers will point out that it is so bad for people's health that fast-food outlets are in effect selling a hazardous product without providing the health warnings you might reasonably expect such goods to carry.  A restauramt that poisons people by selling food laced with salmonella is quickly brought to book.  Is it less blameworthy to sell food loaed with calories that give people chronic disease.?    Like it or not, it's [legal action against obesity] a struggle that looks necessary if we are to halt the obesity epidemic.  Admonitions from nutritionalists, politicians, and health educators seems to have little effect.  And history suggests that without the sustained pressure of a legal attack, the food industry is unlikely to mend its ways. New Scientist

 Barber's class-action lawsuit was the first volley in a long-awaited legal assault against the fast-food industry and its role in the obesity epidemic that is swamping the US health-care system. Inspired by the success of Big Tobacco, the lawyers behind it believe they can force fast-food chains to meet their fair share of the enormous cost of caring for obesity. Pulling the strings is John Banzhaf, of George Washington University Law School in Washington DC, who masterminded the Big Tobacco crusade.

 New and potentially explosive findings on the biological effects of fast food suggest that eating yourself into obesity isn't simply down to a lack of self-control. Some scientists are starting to believe that bingeing on foods that are excessively high in fat and sugar can cause changes to your brain and body that make it hard to say no. A few even believe that the foods can trigger changes that are similar to full-blown addiction.

 Banzhaf maintains that he can win regardless. He points out that he doesn't have to prove that the fast-food chains are entirely responsible for obesity. All he has to do is convince a jury that his clients' health problems were not entirely their own fault -- that the fast-food companies share the blame. Perhaps, for example, they should have labelled the food to inform customers of its high calorific value.  Any hint that the food is addictive, though, would make Banzhaf's job a great deal easier. And he knows it. Banzhaf already says he believes that fast food has "addictive-like" properties. "We might even discover that it's possible to become addicted to the all-American meal of burgers and fries," he says.

  But how can something you need for survival be addictive? The answer could be in the food itself. The difference between a fast-food meal and a home-cooked one is the sheer quantity of calories and fat it delivers in one go. The US Department of Agriculture's recommended daily intake for a normal adult male is 2800 kilocalories (11,723 kilojoules) and a maximum of 93 grams of fat. A meal at a fast-food outlet -- burger, fries, drink and dessert -- can deliver almost all of that in a single sitting. Biologists are now starting to realise that a binge of these proportions can trigger physiological changes which mute the hormonal signals that normally tell you to put down the fork.

  The problem is, people who gain weight develop resistance to leptin's power, explains Michael Schwartz, an endocrinologist at the University of Washington in Seattle. "Their brain loses its ability to respond to these hormones as body fat increases," he says. The fatter they get, and the more leptin they make, the more insensitive the hypothalamus becomes. Eventually the hypothalamus interprets the elevated level as normal -- and forever after misreads the drops in leptin caused by weight loss as a starvation warning.

  But you don't need to become overweight to perturb your leptin system. The latest research suggests that it only takes a few fatty meals. In a study published in December, physiologist Luciano Rossetti of the Albert Einstein College of Medicine in New York City fed rats a high-fat diet and found that after just 72 hours the animals had already lost almost all of their ability to respond to leptin (Diabetes, vol 50, p 2786). The good news, says Rossetti, is that these changes are reversible. "But the fatter a person becomes the more resistant they will be to the effects of leptin and the harder it is to reverse those effects."

 Sarah Leibowitz, a neurobiologist at Rockefeller University in New York City, has more evidence that eating fast food is self-reinforcing. Her experiments show that exposure to fatty foods may quickly reconfigure the body's hormonal system to want yet more fat. She has shown that levels of galanin, a brain peptide that stimulates eating and slows down energy expenditure, increase in rats when they eat a high-fat diet.  In fact, Leibowitz has found that it only takes one high-fat meal to stimulate galanin expression in the hypothalamus. When the effects of galanin are blocked, the animals eat much less fat. "The peptide is itself responsive to the consumption of fat, which then creates the basis for a vicious cycle," she says.

 What's more, early exposure to fatty food could reconfigure children's bodies so that they always choose fatty foods. Leibowitz found that when she fed young rats a high-fat diet, they invariably became obese later in life. She is still investigating what's going on, but her theory is that an elevated level of fats called triglycerides in the bloodstream turns on genes for neuropeptides such as galanin that promote overeating. This suggests that children fed kids' meals at fast-food restaurants are more likely to grow up to be burger-scoffing adults.

 Rossetti's most recent studies have also found a connection between triglycerides and food intake. Using a catheter implanted in the brain, Rossetti delivered lipids directly into the arcuate nucleus -- a region of the hypothalamus -- to either normally fed rats or overfed rats, and then measured their food intake for three days. In the normally fed group the excess fats curbed food intake by up to 60 per cent. But the overfed rats just carried on scoffing. What's more, Rossetti discovered that this effect is not dependent on the composition of the diet, whether high-fat or high-sugar, but instead depends on the total amount of calories.

 Hormonal changes may remove some element of free will, but on its own that hardly means that fast food is addictive. However, there is another strand of research that suggests gorging on fat and sugar causes brain changes normally associated with addictive drugs such as heroin.  Repeated use of addictive substances is thought to alter the circuitry in as yet unknown ways.

 John Hoebel, a psychologist at Princeton University in New Jersey, is interested in whether it is possible to become dependent on the natural opioids released when you eat a large amount of sugar. Along with a team of physiologists from the University of the Andes in Merida, Venezuela, Hoebel recently showed that rats fed a diet containing 25 per cent sugar are thrown into a state of anxiety when the sugar is removed. Their symptoms included chattering teeth and the shakes -- similar, he says, to those seen in people withdrawing from nicotine or morphine. What's more, when Hoebel gave the rats naloxone, a drug that blocks opioid receptors, he saw a drop in dopamine levels in the nucleus accumbens, plus an increase in acetylcholine release. This is the same neurochemical pattern shown by heroin addicts as they go into opioid withdrawal (Obesity Research, vol 10, p 478). "The implication is that some animals -- and by extension some people -- can become overly dependent on sweet food," says Hoebel. "The brain is getting addicted to its own opioids as it would morphine or heroin. Drugs give a bigger effect, but it's essentially the same process."

 As yet no one knows how a big hit of fat and sugar compares with a dose of, say, heroin. But Hoebel says: "Highly palatable foods and highly potent sexual stimuli are the only stimuli capable of activating the dopamine system with anywhere near the potency of addictive drugs."

  Ann Kelley, a neuroscientist at the University of Wisconsin Medical School in Madison, has uncovered more evidence that the release of opioids in the nucleus accumbens tells your brain to keep eating. She found that if rats' opioid receptors are overstimulated with a synthetic enkephalin, the rats eat up to six times the amount of fat they normally consume. They also raise their intake of sweet, salty and alcohol-containing solutions, even when they are not hungry.  Kelley has also discovered that rats that overindulge in tasty foods show marked, long-lasting changes in their brain chemistry similar to those caused by extended use of morphine or heroin. When she looked at the brains of rats that received highly palatable food for two weeks, she saw a decrease in gene expression for enkephalin in the nucleus accumbens. "This says that mere exposure to pleasurable, tasty foods is enough to change gene expression, and that suggests that you could be addicted to food," says Kelley.